Birinapant

  • Mechanism

    SMAC mimetic (Intravenous)

  • Disease areas

    Head & Neck cancer (with radiation)

Birinapant - for the treatment of solid tumors

Birinapant is a SMAC mimetic that was acquired from TetraLogic Pharmaceuticals Corporation (TetraLogic) in 2016 and has since then been developed by Medivir for the treatment of solid tumors. Birinapant has the potential, in combination with other pharmaceuticals, to improve treatment response and prolong survival among patients with solid tumors for whom available treatments provide insufficient survival, or for patients who no longer have any treatment options.

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Partner

IGM Biosciences Inc.

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Project status and Medivir participation

In January 2021 Medivir entered into an exclusive licensing agreement, through which IGM Biosciences Inc., will receive global, exclusive development rights for birinapant. IGM intends to initiate clinical studies with birinapant in combination with its inhouse-developed antibody IGM-8444, during 2021. The combination of IGM-8444 and birinapant has been shown to enhance anti-tumor activity preclinically.


According to the agreement, Medivir received an upfront payment of USD 1 million upon signing the agreement, followed by an additional USD 1.5 million when birinapant is included by IGM in clinical phase I studies. The terms of the agreement furthermore entitle Medivir, should birinapant be successfully developed and approved, to receive milestone payments up to a total of approximately USD 350 million, plus tiered royalties up to mid-teens on net sales. TetraLogic will receive part of total revenues but the main part will accrue to Medivir.

Presentation held at the announcement of the licensing agreement.

Projects from our team

MIV-818

Nucleotide DNA polymerase inhibitor (oral)

Remetinostat

HDAC inhibitor (topical)

MIV-711

Cathepsin K inhibitor (oral)