| Protease libraries - These compound libraries consist
of designed specific inhibitors of proteases and
are excellent starting points to discover hit and
lead molecules of protease targets.
RAPiD - This technology consists of a large
library of FRET-based tetrapeptide sequences that
act as substrates for a diverse range of proteases.
They are constructed in such a way that cleavage
of the peptide by a protease can be easily detected
and measured. From this approach the preferred cleavage
sequence of any protease can be precisely determined.
This provides valuable information on SAR and small-drug
inhibitor design.
e-FOCUS - This is a sophisticated software
designed to assimilate the data from RAPiD and to
give an analysis of the preferred cleavage site
of a protease. This information is used by Medivir
chemists to design specific inhibitors of protease
targets.
X-ray crystallography - Medivir has all
of the necessary technologies and expertise to generate
large amounts of recombinant proteins. These proteins
may be used to produce crystals or are co-crystallized
with in-house inhibitors which may be analysed using
our in-house equipment to give a precise structural
model of how our inhibitors bind to their targets.
This information is used to improve the properties
of our molecules.
Polymerase libraries - These compound libraries
are either nucleoside or non-nucleoside inhibitors
of polymerases. They represent excellent starting
points to discover hit and lead molecules of polymerase
targets.
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