TMC435 (HCV protease)

Therapy Area
Treatment of hepatitis C virus (HCV) infection.

Phase
Phase I studies completed and reported. Phase IIa studies in patients are ongoing.
Competitive Edge
Novel HCV NS3/4A protease inhibitor with excellent antiviral activity in the replicon cell-based assay. Good oral bioavailability.
Project data
  • Collaboration with Tibotec since 2004
  • Phase IIa studies ongoing
  • Excellent antiviral activity in cellbased assays
  • Very good oral bioavailability
  • Several series of potent inhibitors have been developed that provide backups
Main products 2006
Pegintron
(Peg-IFN) Schering-Plough
Intron A (IFN) Schering-Plough
Rebetol (Ribavirin) Schering-Plough
Pegasys (Peg-IFN) Roche
Copegus (Ribavirin) Roche

Last Modified: 06/11/2008